I’m a big fan of the MIT Technology Review’s annual list of ten breakthrough technologies—so when they asked me to choose this year’s list, I jumped at the chance. It’s been a lot of fun working on the issue and picking which innovations to include. I think all ten entries will have a significant impact in the years to come, and I’m excited for you to learn more about them.

Here’s the opening essay I wrote for the issue. You can see the full list of breakthrough technologies here.

I was honored when MIT Technology Review invited me to be the first guest curator of its 10 Breakthrough Technologies. Narrowing down the list was difficult. I wanted to choose things that will not only create headlines in 2019 but captured this moment in technological history—which got me thinking how innovation has evolved over time.

My mind went to—of all things—the plow. The plow is an excellent embodiment of the history of innovation. Humans have been using them since 4000 BCE when Mesopotamian farmers used sharpened sticks to aerate soil. We’ve been slowly tinkering with and improving them ever since, and today’s plows are technological marvels.

But what exactly is the purpose of a plow? It’s a tool that creates more: more seeds planted, more crops harvested, more food to go around. In places where nutrition is hard to come by, it’s no exaggeration to say that a plow gives more years of life to people. The plow—like many technologies, both ancient and modern—is about creating more of something and doing it more efficiently, so that more people can benefit.

Contrast that with lab-grown meat, one of the innovations I picked for this year’s TR10 list. Growing animal protein in a lab isn’t about feeding more people. There’s enough livestock to feed the world already, even as demand for meat goes up. Next-generation protein isn’t about creating more—it’s about making meat better. It lets us provide for a growing and wealthier world without contributing to deforestation or emitting methane. It also allows us to enjoy hamburgers without killing any animals.

Put another way, the plow improves our quantity of life, and lab-grown meat improves our quality of life. For most of human history, we’ve put most of our innovative capacity into the former. And our efforts have paid off: worldwide life expectancy jumped from 34 years in 1913, to 60 in 1973, and has reached 71 today.

Because we’re living longer, our focus is starting to shift toward well-being. This transformation is happening slowly. If you divide scientific breakthroughs into these two categories—things that improve quantity of life versus quality of life—the TR10 list from 2009 looks not so different from this year’s. Like most forms of progress, the change is so gradual that it’s hard to perceive. It’s a matter of decades, not years—and I believe we’re only at the midpoint of the transition.

To be clear, I don’t think humanity will stop trying to extend lifespans anytime soon. We’re still far from a world where everyone everywhere lives to old age in perfect health, and it’s going to take a lot of innovation to get us there. Plus, “quantity of life” and “quality of life” are not mutually exclusive ideas. A malaria vaccine would both save lives and make life better for children who might have otherwise been left with developmental delays from the disease.

We’ve reached a point where we’re tackling both ideas at once, and that’s what makes this moment in history so interesting. If I had to predict what the TR10 will look like a few years from now, I bet technologies that alleviate chronic disease will be a big theme. This won’t just include new drugs (although I would love to see new treatments for diseases like Alzheimer’s on the list). These innovations might look like a mechanical glove that helps a person with arthritis maintain flexibility or an app that connects someone experiencing a major depressive episode with the help they need.

If we could look even further out—let’s say the TR10 list 20 years from now—I would hope to see technologies that center almost entirely on well-being. I think the brilliant minds of the future will focus on more metaphysical questions: How do we make people happier? How do we create meaningful connections? How do we help everyone live a fulfilling life? 

I would love to see these questions shape the 2039 list, because it would mean that we’ve successfully fought back disease (and dealt with climate change). I can’t imagine a greater sign of progress than that. For now, though, the innovations driving change are a mix of things that extend life and things that make it better. My picks reflect both. Each one gives me a different reason to be optimistic for the future, and I hope they inspire you, too.

My selections include amazing new tools that will one day save lives, from simple blood tests that diagnose cancer to toilets that destroy deadly pathogens. I’m equally excited by how other technologies on the list will improve our lives. Wearable health monitors like the wrist-based EKG will warn heart patients of impending problems, while others let diabetics not only track glucose levels but manage their disease. Advanced nuclear reactors could provide carbon-free, safe, and secure energy to the world.

One of my choices even offers us a peek at a future where society’s primary goal is personal fulfillment. Among many other applications, AI-driven personal agents might one day make your email inbox more manageable—something that sounds trivial until you consider what possibilities open up when you have more free time.

The thirty minutes you used to spend reading emails could be spent doing other things. I know some people would use that time to get more work done—but I hope most would use it for more fulfilling pursuits, like connecting with a friend over coffee, helping your child with her homework, or even volunteering in your community.

That, I think, is a future worth working toward.